منابع مشابه
Pyrimethamine inhibits renal secretion of creatinine.
The mechanism of increased serum creatinine after administration of pyrimethamine and dapsone was evaluated for six healthy volunteers. Serum parameters, urine sediment, and clearances of creatinine, inulin, and para-aminohippurate were assessed prior to and 28 h after the ingestion of a single, combined dose of 100 mg of pyrimethamine and 200 mg of dapsone. In a second series, the same renal f...
متن کاملCreatinine content of urine and bacterial growth.
SIRy-Mr. W. L. Whitehouse (21 June, p. 759), like myself' and many others, again calls attention to the potential dangers of rhesus isoimmunization in therapeutic abortion. He asks that the extent of this problem be further and scientifically investigated. There are, in fact, one or two further facets to be considered. Firstly, all of us are aware of the numbers of women whose first continuing ...
متن کاملPomegranate peel extract inhibits internalization and replication of the influenza virus: An in vitro study
Objective: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it are limited. Our previous study showed anti-influenza virus activity of pomegranate peel extract (PPE). In this study, the mechanism through which PPE acts against influenza virus...
متن کاملA bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.
Toxin-antitoxin (TA) systems are ubiquitous on bacterial chromosomes, yet the mechanisms regulating their activity and the molecular targets of toxins remain incompletely defined. Here, we identify SocAB, an atypical TA system in Caulobacter crescentus. Unlike canonical TA systems, the toxin SocB is unstable and constitutively degraded by the protease ClpXP; this degradation requires the antito...
متن کاملA hybrid bacterial replication origin.
We constructed a hybrid replication origin that consists of the main part of oriC from Escherichia coli, the DnaA box region and the AT-rich region from Bacillus subtilis oriC. The AT-rich region could be unwound by E. coli DnaA protein, and the DnaB helicase was loaded into the single-stranded bubble. The results show that species specificity, i.e. which DnaA protein can do the unwinding, resi...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2012
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2011.131